Ebenezer Zane (1747-1811) was an American pioneer and land speculator. Born in what is now Moorefield, West Virginia (which was then in the state of Virginia), Zane established the settlement known as Fort Henry in Wheeling, Virginia (present day West Virginia) on the Ohio River. Zane is also famous for blazing the trail known as Zane's Trace.

At Fort Henry
Following the war in 1796, Zane obtained permission and funds from the United States Congress to build a road through the Northwest Territory. In exchange for his work, Congress granted Zane tracts of land in the areas where the road intersected the Muskingum, Hocking, and Scioto rivers.
When Zane's Trace was completed, it crossed what is now the state of Ohio from Wheeling, Virginia to Maysville, Kentucky. Although the road was a rudimentary path and was only suitable for travel by foot or horseback (and not by wagon), it was the only major road in Ohio until the War of 1812. See the entry on Zane's Trace for more information.
Zanesville, Ohio was named in his honor, and he was a maternal ancestor of author Zane Grey who was born there. Ebenezer Zane died of jaundice in 1811.